Opis
“Ocular Oncology” reflects a broad scope of expertise based on many years of work of the Authors. It is worth pointing out that all the Authors are eminent and internationally recognized specialists in ophthalmic oncology, who shared their experience with the readers. The book's great didactic value are numerous illustrations such as color photographs, photographs in infrared light and autofluorescence, ultrasound examinations and optical coherence tomography as well as fluorescein and indocyanine angiography. The publication is a unique proposition for ophthalmologists, oncologists, oncological surgeons, radiotherapists and residents specializing in described topics. The book is also available in Polish language. Książka „Onkologia okulistyczna” jest odzwierciedleniem wieloletniej pracy i ogromnej wiedzy autorów – wybitnych międzynarodowych specjalistów – wnikliwych znawców tematu, którzy starali się przekazać swoją wiedzę czytelnikom. Ogromną wartość dydaktyczną książki stanowią bardzo liczne ryciny: barwne fotografie, fotografie w świetle bezczerwiennym i autofluorescencji, badania ultrasonograficzne i optycznej koherentnej tomografii oraz angiografia fluoresceinowa i indocjaninowa). Publikacja to unikatowa propozycja dla okulistów, onkologów, chirurgów onkologicznych, radioterapeutów i studentów wiążących swoją przyszłość z tymi specjalizacjami. Jest dostępna również w języku polskim. Spis treściAbbreviations XVI 1. History of ocular tumor radiotherapy in Krakow – Bożena Romanowska-Dixon, Barbara Jakubowska 1 2. Genetic aspects of ocular tumours – Jakub Khzouz, Sarah E. Coupland 11 Introduction 11 Eyelid cancers 11 Basal cell carcinoma 11 Sebaceous carcinoma 13 Merkel cell carcinoma 14 Conjunctival cancers 15 Conjunctival squamous carcinoma and pre-invasive lesions 15 Conjunctival melanoma 17 Conjunctival lymphomas 18 Intraocular cancers 19 Medulloepithelioma 19 Retinoblastoma 20 Uveal melanoma 22 Vitreoretinal Lymphoma 23 Summary 24 3. Immunology of ocular tumors – Martine J. Jager, Jinfeng Cao 27 Introduction 27 Immune checkpoint inhibitors 27 Uveal melanoma: effect of checkpoint inhibitors 28 Other therapies 29 Presence of inflammation in UM 29 Phenotype-genotype comparisons 29 Comparison to other tumors 30 Conjunctival melanoma 31 Side effects of treatment 32 Conclusions 32 4. Eyelid tumors – Joshua Ford, Bita Esmaeli 35 Introduction 35 Overview of eyelid malignancies 36 Basal cell carcinoma (BCC) 36 Squamous cell carcinoma 37 Sebaceous carcinoma (SebC) 37 Periocular sweat gland carcinoma 38 Merkel cell carcinoma 38 Malignant hair follicle carcinoma 39 Eyelid melanoma 39 American Joint Committee on Cancer Staging (TNM) of eyelid malignancies 40 Surgical management 40 Basal cell carcinoma 40 Squamous cell and sebaceous cell carcinoma 40 Eyelid melanoma 41 Merkel cell 41 Sentinel lymph node biopsy (SLNB) 41 Adjuvant therapies 42 Topical therapies – Imiquimod (Aldara) 42 Targeted therapies 42 BRAF targeted therapy (vemurafenib, sorafenib, debrafenib) 43 Immune checkpoint inhibitors (pembrolizumab, ipilimumab, nivolumab, 43 Other therapies 44 Summary 44 5. Conjunctival tumors – Bożena Romanowska-Dixon, Barbara Jakubowska 49 Benign conjunctival tumors 50 Vascular lesions of the 60 Pigmented 69 Congenital and acquired melanosis 70 Malignant conjunctival tumors 76 Conjunctival squamous intraepithelial neoplasia (CIN; also termed C-SIN) 76 Invasive conjunctival squamous cell carcinoma (SCC) 76 Conjunctival melanoma 80 Lymphoid tumors 90 Metastatic tumors 94 Secondary conjunctival tumors 95 Differential diagnosis of conjunctival tumors 95 Conclusion 102 6. Uveal tumors 105 Iris cyst – Bożena Romanowska-Dixon, Barbara Jakubowska 105 Uveal nevi and melanoma – Bożena Romanowska-Dixon, Barbara Jakubowska 123 Iris nevus 124 Iris melanoma 140 Iris metastases 161 Ciliary body tumors – Bożena Romanowska-Dixon, Barbara Jakubowska 166 Ciliary body cyst 166 Ciliary body and peripheral choroidal melanoma 168 Ciliary body metastases 175 Ciliary body adenoma and ciliary body adenocarcinoma 176 Differential diagnosis of ciliary body tumors 176 Choroidal tumors 181 Choroidal hemangioma – Bożena Romanowska-Dixon, Barbara Jakubowska 181 Choroidal osteoma – Bożena Romanowska-Dixon, Barbara Jakubowska 201 Sclero-choroidal calcifications – Bożena Romanowska-Dixon, Barbara Jakubowska 211 Choroidal pigmented tumors – Bożena Romanowska-Dixon, Barbara Jakubowska, Izabella Karska-Basta 215 Management of ciliary body and/or choroidal melanoma 277 Surgical treatment – Bożena Romanowska-Dixon, Agnieszka Kubicka-Trząska 277 Endoresection of choroidal melanoma – Agnieszka Kubicka-Trząska 277 Exoresection – Bożena Romanowska-Dixon 282 Enucleation – Bożena Romanowska-Dixon, Barbara Jakubowska 285 Radiotherapy – Bożena Romanowska-Dixon, Barbara Jakubowska 295 Prediction of metastatic disease in patients with choroidal melanoma – Bertil 314 Intraocular metastases – Bożena Romanowska-Dixon, Barbara Jakubowska 317 Introduction 317 Diagnosis 318